Expanding the network of autoantibodies in patients with normal results from a classic test (aCL, LA and/or β2GPI) using new antibodies (i.e., PT/PS and β2GPI domain 1) in patients with suspected APS would increase the diagnostic capability of detection of new cases of APS formerly labeled as “seronegative” cases [13]. The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.