The updated classification criteria for definite antiphospholipid syndrome (APS), also known as Hughes syndrome, specifies anticardiolipin (aCL) and anti-β2-glycoprotein I (β2GPI) antibodies of IgG and/or IgM isotype in medium or high titer as one of the laboratory criteria [1]. Here, CD40LG is linked to antiphospholipid syndrome.