Anti-β2GP1 antibodies isolated from primary APS patients are considered to be poly-reactive, as they have been found to react against several domains of β2GP1, such as DV (52.9%–64.6%), DIV (45.8%), DI–II (33.1%), and DIII (20.5%) [88]. The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.