In the PNS, specifically in MG, anti-AChR autoantibodies accelerate the internalization of the receptor [88,89], a mechanism that can be blocked by overexpression of the AChR anchoring protein, rapsyn, in an experimental passive transfer MG model, showing the important role of anchoring proteins in the resistance to the autoantibody attack [90]. The gene discussed is CELSR3; the disease is myasthenia gravis.