In the Psychiatric Genomics Consortium, single nucleotide polymorphisms (SNPs) in two l-type voltage-gated calcium channel subunits, voltage-gated calcium channel subunit alpha1 C (CACNA1C) and calcium voltage-gated channel auxiliary subunit beta2 (CACNB2), were identified as common risk factor among all studied diagnosis including ASD, ADHD, BD, MDD and schizophrenia [35]. This evidence concerns the gene CACNA1C and major depressive disorder.