CDH3 and neoplasm: While all DART proteins showed specific binding to cell surface-expressed P-cadherin, only DARTs 33, 34 and 35 showed P-cadherin-specific lysis, with EC50 values in the range of 0.1–4 nM on tumor lines and 0.03–0.74 nM on CHO cells transfected with P-cadherin (Figure 2A, Figure S5B, and Table 1).