Thus, high levels of anti-phospholipid IgM antibodies (β2GP1, cardiolipin) in lupus patients have been found to be associated with less frequent renal disease manifestations [206]; anti-dsDNA IgM have been inversely correlated with glomerulonephritis in SLE [64,65] and the diverse profile of autoreactive IgM antibodies detected in lupus patients by microarray studies was correlated with lower disease activity [207]. This evidence concerns the gene CD40LG and systemic lupus erythematosus.