In vitro studies have shown that this anti-CD20 × CD47 bsAb, through tumor targeting and CD47 blockade, guided the macrophage attack and induced an efficient phagocytosis of malignant cells in a FcγR-dependent manner, which translated in vivo by a reduced lymphoma burden and an increased mice survival [173]. The gene discussed is FCGR2A; the disease is neoplasm.