Interestingly, the depletion of Lgr5+ cells ceases tumor growth of CRC, yet tumor growth is restored by the spontaneous reappearance of Lgr5+ cells in a dedifferentiation event in the primary tumor but not in the metastatic liver site, suggesting the absence of a CSC-supportive niche in the liver [30,138]. This evidence concerns the gene LGR5 and neoplasm.