GZMB and Sepsis: In guinea pigs with LPS-induced sepsis, where mRNA and protein levels of GRα decreased and protein expression of GRβ increased in the injured lungs, high-dose methylprednisolone (40 mg/kg i.p.)administered simultaneously with LPS potentiated the decrease in expression of GRα and influenced expression of GRβ what impaired GRα nuclear translocation, but strongly blocked sepsis-induced NF-κB activation and transmigration of inflammatory cells into BALF [47].