CRP and Shock: In the RCT included patients admitted to ICU with severe community-acquired pneumonia (CAP), treatment with hydrocortisone (200 mg i.v. bolus followed by an infusion of 10 mg/h for seven days) improved PaO2/FiO2 and MODS score by day 8, reduced concentrations of C-reactive protein (CRP), delayed septic shock, reduced duration of hospital stay and mortality [84] (Table 1).