All samples obtained from patients with high-risk disease after rapid COJEC chemotherapy treatment, exhibit TPX2 expression increased too (TPX2+ cells 93 ± 3% on average vs. 27 ± 2% in the untreated tumor; p < 0.001) (Figure 5A(5,6) and Figure 5B), suggesting that TPX2 protein level is closely connected to DNA damage response in NB, and can confer upon the resistant cells the capability to rescue and to reproduce themselves again (Figure 5A(7)). This evidence concerns the gene TPX2 and neoplasm.