Likewise, increased WNT-5B expression in COPD has been linked to pro-inflammatory signaling functions [31,32] However, A. Nabhan et al. recently demonstrated that WNTs including WNT-5A expressed by the fibroblasts activate the canonical WNT signaling pathway in neighboring AT2 cells to facilitate regeneration [33]. This evidence concerns the gene WNT5B and chronic obstructive pulmonary disease.