INS and type 2 diabetes mellitus: Additionally, the treatment with the water-ethanolic extract of green macroalgae Enteromorpha prolifera reduced the inflammation in the liver and kidney by significantly increasing the abundance of Lachnospiraceae and Alisties as well as regulating the insulin signaling pathway in T2DM mice induced by HFD and high sucrose diet (HSD) and streptozotocin [107].