HIF1A and hemangioma: Moreover, the hemangioma endothelial cells exhibit increased level of hypoxia-inducible factor 1-alpha (HIF-1α) compared to the control cells due to the promotion of VEGF/VEGF2 signaling pathway [100] while its remediation with rapamycin down-regulated the HIF-1α and VEGF-A165 and meaningfully decreases the volume of kidney tumors [101].