Snail1, a NF-κB target gene [88,108,125], was also shown to suppress p53 by forming a tri-molecular Snail1/HDAC1/p53 complex, which deacetylates activated p53 to promote its proteasomal degradation, leading to an increased expansion of tumor-initiating cells in human breast cancer [103]. The gene discussed is SNAI1; the disease is breast carcinoma.