TNFα-mediated S276 phosphorylation of RelA/p65 by PKA (protein kinase A) or MSK1 (mitogen and stress-activated protein kinase-1) is required for RelA/p65-DNMT1 interactions, chromatin binding of DNMT1, and subsequent BRMS1 gene promoter methylation, leading to its transcriptional repression in NSCLC cells [185]. Here, TNF is linked to non-small cell lung carcinoma.