In addition to enhancing cancer cell proliferation and survival, IL-6 induces EMT via JAK-STAT3 or NF-κB pathways, leading to the induction of several EMT-TFs such as Snail, Slug, Twist, and Zeb1, which suppress the expression of CDH1 via the recruitment of epigenetic regulators. The gene discussed is STAT3; the disease is cancer.