For example, loss of TGFβ-mediated tumor suppression occurs via two distinct mechanisms involving the acquisition of loss-of-function mutations of core TGFβ signaling pathway components such as TGFβRII and Smad4, the epigenetic silencing of TGFβRII, and the decoupling of growth inhibition and apoptosis, and stimulating EMT, cell migration and invasion [15,79,144,147,152,154,155,156,157]. Here, TGFB1 is linked to neoplasm.