Activation of IL-1β/IL–1RI/β-catenin signaling pathway was shown to activate EMT in a breast cancer cell model through the formation of a TCF/Lef/β-catenin complex leading to the sequential induction of c-Myc, CCDN1, Snail1, MMP2, and BIRC3 (cIAP2) expression. The gene discussed is SNAI1; the disease is breast carcinoma.