TNFα-mediated activation of canonical NF-κB signaling leads to the induction of multiple EMT-TFs, including Twist1 [119,176,177], Snail [89], Snail2 (Slug) [90], and Zeb1/2 [178], and to the repression of E-cadherin expression, and NF-κB-dependent cell migration and invasion in breast cancer cells. This evidence concerns the gene SNAI2 and breast cancer.