TP53 deficiency induces loss of IL-6 promoter methylation, leading to an autocrine IL-6 loop, which induces epigenetic reprogramming to drive cancer cells towards a CSC-like phenotype [238,241,242], via up-regulation of DNMT1 [238,239] by acetylated STAT3 at Lys685 [244]. The gene discussed is STAT3; the disease is cancer.