Moreover, IL-1β induces ICI-EMT in a 6D breast cancer cell model by activating the IL-1β/IL–1R1/β-catenin pathway and up-regulating Twist1, leading to ESR1 gene promoter methylation, and to methylation-dependent down-regulation of ERα receptor, linked to tamoxifen resistance [207]. This evidence concerns the gene IL1B and breast cancer.