On the other hand, in solid cancers where STAT5 plays a causal role such as liver and prostate cancer, in addition to SOCS3, SOCS1 is frequently inactivated and mouse models of SOCS1 ablation increase both liver and prostate tumorigenesis [125,126,127,128,129,130,131,132]. The gene discussed is STAT5B; the disease is prostate carcinoma.