HSP70 overexpression has been associated with a poor prognosis in melanoma, cholangiocarcinoma, colon cancer, bladder cancer, breast cancer and uterine cervical cancer [3,24], and HSP70 is a survival factor that enhances carcinogenesis, is antiapoptotic in nature and is highly expressed in tumors [75]. The gene discussed is HSPA1A; the disease is melanoma.