Evaluation of the performance of a five-marker signature including AREG, MASP1, OPN, PON3, and TR yielded AUCs of 0.82 (95% CI, 0.74–0.89), 0.86 (95% CI, 0.77–0.92), and 0.76 (95% CI, 0.64–0.86) for all, early, and late stage CRC detection, respectively, in the validation set. This evidence concerns the gene AREG and colorectal carcinoma.