PON3 and colorectal carcinoma: When LASSO with .632+ bootstrap was applied on the eleven protein biomarkers and additionally AREG measurements of PEA in the discovery set, a five-marker signature (AREG, MASP1, OPN, PON3, and TR) was obtained and improved AUCsBS of 0.87, 0.81, and 0.92 were observed for all, early, and late CRC detection.