In 2006, Kwon et al. found that the WEBC (100, 250 and 500 mg/kg) can completely prevent streptozotocin (STZ)-induced diabetes in mice via inhibiting the expression of iNOS and the activation of NF-κB, Moreover, WEBC (0.125, 0.25, 0.5 and 1.0 mg/mL) decreased the production NO and the expression of iNOS mRNA induced by IL-1 β and TNF-γ, which can completely protect rat insulinoma RINm5F cells against IL-1 β and TNF- γ-induced cytotoxicity [3]. Here, NOS2 is linked to diabetes mellitus.