MMP2 and cervical cancer: In 2010, Koppikar et al. reported that water extracts of barks of C. cassia (WEBC) can change the growth kinetics of a cervical cancer cell line (SIHA) and down-regulate MMP-2, decreasing the cell mobility in a dose-dependent manner, WEBC can induce apoptosis of cervical cancer cells by increasing intracellular calcium signal and loss of mitochondrial membrane potential [68].