Moreover, Chou et al. reported that EOC (1.0, 2.0, 2.5 and 5.0 μg/mL) and trans-cinnamaldehyde (1.0, 2.0 and 2.5 μg/mL) reduced the melanin content and tyrosinase activity of the cells, down-regulated tyrosinase expression without exhibiting cytotoxicity, decreased thiobarbituric acid-reactive substance (TBARS) levels and restored glutathione (GSH) and catalase activity in murine B16 melanoma cells stimulated with α-melanocyte-stimulating hormone (α-MSH) (IC50 = 6.16 ± 0.04 and 4.04 ± 0.08 mg/mL, respectively) [101]. The gene discussed is TYR; the disease is melanoma.