Additionally, an investigation in 2015 indicated that EOTC can significantly inhibit the growth of different cell lines (FaDu, Detroit-562, SCC-25) of head and neck squamous cell carcinoma (HNSCC) by inhibiting the active site of EGFR-TK, and also significantly inhibit the tumor growth in a Hep-2 cell xenotransplantation model [53]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.