APOE and Alzheimer disease: These differences of APOE allele frequency in the MA population could indicate different disease risks; for instance, the E4 allele that confers a higher risk of coronary artery disease (CAD) or AD, in the MA populations is less frequent and could be important in the modulation of lower risk for CAD or AD that has been previously reported for Hispanic populations (Fujiyoshi et al., 2017; Maestre et al., 1996).