APOE and early-onset autosomal dominant Alzheimer disease: Additionally, each isoform of ApoE conveys a different risk of some diseases, such as Alzheimer's disease (AD) (Chen, Baum, Ng, Chan, & Pang, 1999) schizophrenia (Vila‐Rodriguez, Honer, Innis, Wellington, & Beasley, 2011), osteoporosis (Singh, Singh, Singh, Juneja, & Kaur, 2010), or arteriosclerosis, which could be due the different functions and structures of the ApoE isoforms (Mahley, Weisgraber, & Huang, 2009; Ray, Ahalawat, & Mondal, 2017).