Our findings on Y37A1B.5 conferring selenite resistance, and its downregulation contributing to oxidative stress resistance and lifespan extension are in line with observations on the human ortholog: SELENBP1 sequesters supplemental Se, and its downregulation in tumor cells decreases their sensitivity to cytotoxic effects of oxidative stressors such as H2O2 and paraquat [42]. The gene discussed is SELENBP1; the disease is neoplasm.