CF impacts about 70,000 people worldwide 6 though phenotype does not correlate well with mutations in CFTR. The high frequency of the disorder facilitated a replicated GWAS, which identified single nucleotide polymorphisms (SNPs) in an intergenic region of chromosome 11p13 that significantly associated with CF lung disease severity.3, 4 The genes mapping closest to these SNPs are two epithelial–selective E twenty‐six (ETS) transcription factors (TFs), ETS homologous factor (EHF) and E74‐like factor 5 (ELF5) on the 5’ side and Apaf‐1‐interacting protein (APIP) on the 3’ side. The gene discussed is ELF5; the disease is cystic fibrosis.