Proper wound response is crucial for injury repair, and this process is delayed in the CF lung.12 Also, EHF enhances the transcription of genes encoding the pro‐inflammatory cytokines interleukin 8 (IL‐8) and C‐X‐C motif chemokine ligand 6 (CXCL6).11, 12 These secreted cytokines are necessary for the recruitment of neutrophils to a site of infection or injury.55, 56 Increasing the neutrophil burden in the CF lung can lead to chronic inflammation and eventual tissue remodelling,57 both of which significantly contribute to patient mortality. This evidence concerns the gene CXCL6 and cystic fibrosis.