Overexpression of TUG1 has been shown to protect the mouse liver against cold‐induced injury by inhibiting apoptosis and inflammation,11 whereas TUG1 knockdown inhibits hyperlipidaemia, decreases inflammatory response and alleviates atherosclerotic lesions.12 COPD is primarily caused by CS‐induced chronic inflammation. The gene discussed is TUG1; the disease is hyperlipidemia.