SEMA3D and metastatic malignant neoplasm in the lymph nodes: Yoshida et al. investigated the biomarkers associated with lymph node metastasis for preoperative diagnoses to minimize lymphadenectomy in cases with low-risk of recurrence, and showed SEMA3D mRNA and TACC2 isoforms expressed through a novel promoter to be promising biomarkers using Cap Analysis Gene Expression (CAGE) [31].