ANGPTL4 and diffuse type adenocarcinoma: More over, such cell autophagy disruption and C-myc oncogene overexpression in gastric cancer was reported to associate with a transformation of epithelial cells into adenocarcinoma and diffuse-type adenocarcinoma.[14] What’s more, the role of ANGPTL4 as tumor suppressor has also been reported.[12] It is also noticed the RNA level of C-myc have no change as an up-regulation of LMX1A in AGS cell line.