DMBA-induced breast cancer rats showed up-regulated levels of ICDH, SHD, MDH, and α-KGDH, and AX-SLN significantly (p < .001) down-regulated the level of mitochondrial TCA cycle enzymes such as ICDH, SHD, MDH, and α-KGDH (Supplementary Table 6). Here, SHD is linked to breast cancer.