MCM5 and cancer: Moreover, the CLMS data show that the Mcm2 C‐terminus is involved in a network of interactions with flexible domains of Orc6, Orc2 and Mcm5, indicating dynamics at the Mcm2‐Mcm5 DNA entry gate (Samel et al, 2014), which could represent an ideal target for the development of inhibitors with potential as anti‐cancer therapy (Gardner et al, 2017), as dynamic interactions have improved druggability characteristics over stable protein interactions (Ulucan et al, 2012; Jubb et al, 2015).