Overall, these data show that TSLP secretion by bulge HF‐SCs and mutant basal keratinocytes stimulates neighboring epidermal cells to hyper‐proliferate, activate p‐STAT5 and induce expression of VEGFα and IL‐6, contributing to the initiation of epidermal hyperplasia and the maintenance of chronic skin inflammation observed in psoriasis lesions. Here, TSLP is linked to psoriasis.