Deferoxamine, an iron chelator, reduced ICH‐induced JNK activation and white matter loss.7 Other reports demonstrated that suppressing P38 MAPK activation confers neuroprotection in rat intracerebral hemorrhage.31, 32 In the present study, we show through transcriptional profiling that the TGF‐β and MAPK pathways contribute significantly to inflammation and WM injury in piglets. The gene discussed is TGFB1; the disease is intracerebral hemorrhage.