First, since PilM, PilN and PilO proteins are found in monoderms and are essential for Tfpa biogenesis, they do not merely constitute an ‘alignment complex’ as they are often referred to in the literature (Craig et al., 2019; McCallum et al., 2019), whose role would be to connect the pilus assembly sub‐complex to the secretin in the OM, simply because there is neither secretin, nor OM in monoderms. Here, SCT is linked to ocular melanoma.