The morbidity and mortality vary widely in different regions.67 A study has shown that circ_100876 is highly expressed in esophageal squamous cell carcinoma (ESCC).57 It can promote cell proliferation, incursion, and distal metastasis, as well as the progress of EMT.57 Circ‐DLG1 was observed to be increased in ESCC tissues, cell lines, and plasma and can significantly promote cell proliferation.58 These results illustrate that circ‐DLG1 may become a novel diagnostic biomarker of ECSS. The gene discussed is DLG1; the disease is esophageal squamous cell carcinoma.