Identification of two microbiome sputum clusters in airways disease, Haemophilus‐high and Haemophilus‐low, at clinical stability is consistent with previous findings at exacerbations.16 The Haemophilus‐high cluster was associated with increased pro‐inflammatory mediators IL1β and TNFα in asthma and COPD. This evidence concerns the gene IL1B and chronic obstructive pulmonary disease.