TDP-43 pathology frequently appears in other neurodegenerative diseases, including AD, argyrophilic grain disease (AGD), dementia with Lewy bodies (DLB), chronic traumatic encephalopathy (CTE), hippocampal sclerosis (HS), and Guam ALS [8, 61, 67, 90, 109, 113, 162]. This evidence concerns the gene TARDBP and neurodegenerative disease.