NPPB and atrial fibrillation: Compared to NB, patients with HFrEF and both nighttime (Supplementary Table 1) and daytime (Supplementary Table 2) CA had more frequently atrial fibrillation, higher LV filling pressures (as expressed by worse diastolic dysfunction and greater LA volume (all p < 0.001) and greater values of NT-proBNP and plasma norepinephrine (all p < 0.001), despite similar neuro-hormonal antagonism therapy.