Given that HIF-1α and HIF-2α have specific and different temporal and functional roles (reviewed Koh and Powis, 2012), it will be interesting to determine if the switch from glycolysis in the acute phase of sepsis to fatty acid oxidation in the later phase is regulated by a switch from HIF-1α to HIF-2α signaling. This evidence concerns the gene EPAS1 and Sepsis.