HIF1A and Sepsis: Studies of LPS challenge in HIF-1 myeloid conditional knockout mice revealed that HIF-1 is a critical determinant of the sepsis phenotype, via the production of pro-inflammatory cytokines resulting in the clinical manifestation of sepsis symptomology including; tachycardia, hypotension, and hypothermia (Peyssonnaux et al., 2007; Fitzpatrick et al., 2018).