HIF1A and Sepsis: Downstream signaling of the TLR's leads to the activation of a wide range of transcription factors which promote the stabilization of HIF-1α during sepsis, including; mitogen-activated protein kinase (MAPK), MAPK phosphatases-1 and NFκB (Frede et al., 2006; Rius et al., 2008; Talwar et al., 2017).