SMARCAD1 and triple-negative breast carcinoma: Such regulation appears to be of high importance for the maintenance of genomic integrity, and accordingly deregulation of the human ortholog of Fun30, SMARCAD1, was found to play a crucial role during the progression of triple-negative breast cancer, which is specifically characterized by an HR-defect (Kubaisy et al., 2016; Arafat et al., 2018).