Overexpression of oncomiRs, miR-21, miR-155, miR-10b, miR-373, and miR-520 was observed in many breast tumors (19), of which oncomiRs, miR-520g, and miR-520h are potentially sponged by two “initiation circRNAs.” Therefore, the axis parallel to Cx43 mRNA loss, denoted by “initiation” Cx43-derived circRNAs and their sponged miRNAs seems to recapitulate phenotypes along BC initiation. This evidence concerns the gene GJA1 and breast cancer.