Nonetheless, pharmacological stimulation of autophagy enhances the clearance of mutant huntingtin preferentially over its wild-type counterpart (Ravikumar et al., 2002), and the beneficial effects of autophagy induction are robustly demonstrated in cell, Drosophila, zebrafish and mouse models of HD (Sarkar et al., 2009). The gene discussed is HTT; the disease is Huntington disease.