APOE and Alzheimer disease: Rapamycin reduced Aβ plaques and tau tangles and rescued their pathology in APP/Tau/PS1 mutant (3xTg-AD) mice (Caccamo et al., 2010; Majumder et al., 2011), APP/PS1 mutant mice (Jiang et al., 2014a), APP mutant mice (Spilman et al., 2010), APOE4 mutant mice (Lin et al., 2017), FTD mice (Wang et al., 2012), and mutant tau mice (Ozcelik et al., 2013; Jiang et al., 2014b; Siman et al., 2015) and Drosophila (Berger et al., 2006).