PPARA and acute liver failure: Since PPARα agonists such as Wy-14 643 and GW7647 could stimulate hepatic lipophagy and attenuate liver injury in mice and patients with acute liver failure (Jiao et al., 2014; Lee J.M. et al., 2014), modulation of PPARα (a nutrient-sensing nuclear receptor) for inducing hepatic autophagy might represent a potential therapeutic target for the treatment of GSDIa.