Autophagy is the primary clearance mechanism for several aggregation-prone proteins, such as amyloid-β, α-synuclein and huntingtin, associated with Alzheimer’s, Parkinson’s and Huntington’s disease, respectively (Nixon, 2013; Menzies et al., 2017); a process termed aggrephagy (Gatica et al., 2018). The gene discussed is HTT; the disease is Huntington disease.