Trehalose was beneficial in APP/PS1 mutant mice (Du et al., 2013), APP mutant mice (Portbury et al., 2017) and mutant tau mice (Rodriguez-Navarro et al., 2010; Schaeffer et al., 2012), while carbamazepine in APP/PS1 mice (Tardiff et al., 2013), 3xTg-AD mice (Zhang et al., 2017), and FTD mice (Wang et al., 2012). Here, PSEN1 is linked to frontotemporal dementia.