AD mice (APP/Tau/PS1 mutant) (Caccamo et al., 2010; Majumder et al., 2011), AD mice (APP/PS1 mutant) (Jiang et al., 2014a), AD mice (APP mutant) (Spilman et al., 2010), AD mice (APOE4 mutant) (Lin et al., 2017), FTD mice (TDP-43) (Wang et al., 2012), FTD mice (tau mutant) (Ozcelik et al., 2013; Jiang et al., 2014b; Siman et al., 2015), FTD Drosophila (Berger et al., 2006). The gene discussed is APOE; the disease is frontotemporal dementia.