TAAR1 and melanoma: Along the same line, and moving from their previous observation that Tα1 and αβ-IFN could stimulate NK cell activity in cyclophosphamide (Cy)-immunosuppressed mice (16), Pica and coauthors demonstrated that mice inoculated with B16 melanoma or Lewis lung carcinoma (LLC) cells had restored NK cell activity if treated with Tα1 and αβ-IFN 10 days after tumor inoculation (17, 18).