Second, Tα1 fused with the Fc domain of human IgG4 plays anti-tumor effects in the 4T1 and B16.F10 tumor xenograft models by upregulating CD86 expression, secreting IFNγ and IL-2, and increasing the number of tumor-infiltrating CD4+ and CD8+ T cells (35). Here, CD4 is linked to neoplasm.