Additionally, treatment of glioma cells with umbilical cord blood-derived stem cells caused inhibition of focal adhesion kinase (FAK)-mediated angiogenesis (92), upregulation of phosphatase and tensin homolog (PTEN) expression in glioma cells, and down-modulation of Akt and PI3K signaling pathway molecules in the nude mice tumors, resulting in the inhibition of migration as well as wound healing characteristics of the glioma cells (93). This evidence concerns the gene AKT1 and glioma.