ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: In CML, the translocation t(9;22) (q34;q11) leads to the constitutively active fusion protein BCR-ABL1 tyrosine kinase which transfers phosphate from ATP to tyrosine residues of various substrates and finally leads to massively increased proliferation and decrease of apoptosis in myeloid precursor cells via multiple downstream signaling pathways (46).