BRAF and colorectal carcinoma: In the 57 pairs of colorectal carcinoma and normal adjacent tissues, the amount of Fn DNA was significantly higher in colorectal carcinoma tissue than in the normal adjacent tissue, except for one patient with proximal colon, MSI-positive and BRAF mutated tumor, in which the level of Fn DNA was 11.88-fold higher in the normal-adjacent tissue (Figure 2B, paired two-tailed Wilcoxon signed rank test, p = 0.0038).