PMS2 and neoplasm: In FFPE CRC tissue, the amount of Fn DNA was associated with proximal tumor location (p = 0.009), MSI-positive (p < 0.0001), BRAF mutated tumors (p = 0.002), and the loss of expression of mismatch-repair proteins MLH1 (p < 0.0001) and PMS2 (p < 0.0001).