Patients undergoing ADT have excellent initial responses, however most cases result in relapse within a few years due to alternative mechanisms of androgen receptor (AR) signaling, AR amplification or alternative splicing, intratumoral androgen production, or adrenal gland testosterone production at which time the disease is termed castration resistant PC (CRPC) and it is currently incurable (3). This evidence concerns the gene AR and pachyonychia congenita.