Our group performed a comparison between the in-house 4-color analysis (CD20/CD5/CD3/CD19; CD20/CD38/CD19/CD5; Igκ/Igλ/CD19/CD5) and the ERIC panel in 462 CLL samples, and identified slight differences in the amount of leukemic cells, with lower MRD values using the ERIC panel (Figure 1) (36). This evidence concerns the gene CD19 and B-cell chronic lymphocytic leukemia.