This was confirmed in a recent single center randomized trial including mostly R/R patients (n = 181) with few high-risk TN CLL with TP53 deletion/mutation (n = 27), where the addition of rituximab to ibrutinib therapy did not improve the 3y-PFS (86.9 vs. 86%) or the 3y-OS (89 vs. 92%) compared to ibrutinib single agent and did not significantly increase the ORR (92% in both arms) or CR rate (26 vs. 20.2%) as best responses, despite the faster achievement of CR and lower level of BM MRD evaluated by 4-color FCM (112). Here, TP53 is linked to B-cell chronic lymphocytic leukemia.