Our group performed a comparison between the in-house 4-color analysis (CD20/CD5/CD3/CD19; CD20/CD38/CD19/CD5; Igκ/Igλ/CD19/CD5) and the ERIC panel in 462 CLL samples, and identified slight differences in the amount of leukemic cells, with lower MRD values using the ERIC panel (Figure 1) (36). Here, CD5 is linked to B-cell chronic lymphocytic leukemia.