Up to 5 years ago, treatment of CLL relied on chemoimmunotherapy with FC or B or Chl combined with rituximab, chosen according to patients' age and comorbidities, and given as a fixed number of 28-days cycles, usually 6; cases with TP53 deletion/mutation were excluded due to their refractoriness to chemoimmunotherapy and treated with steroids, alemtuzumab and SCT, if eligible. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.