It was shown that crotalase - a kallikrein-likeenzyme isolated from the venom of Crotalus adamanteus - inhibitedthe growth of B16 melanoma cells in vivo through defibrinogenationof mice, but this enzyme does not have a direct cytotoxic or cytostatic effect oncancer cells in vitro [28].SVMPs are the snake venom hemorrhagic metalloproteinases that have differentbiological properties. Here, KLK4 is linked to melanoma.