For example, direct correlations have been established between mutations in CHST6, UBIAD1, SLC4A11, PIKFYVE, TACSTD2, and DCN with macular corneal dystrophies (MCD) (Akama et al., 2000), Schnyder CD (Nowinska et al., 2014a), congenital hereditary endothelial dystrophy (Vithana et al., 2006), fleck CD (Li et al., 2005), gelatinous drop-like CD (Tsujikawa et al., 1999), and congenital stromal CD (Bredrup et al., 2010), respectively. This evidence concerns the gene PIKFYVE and Cowden disease.