For instance, different mutations in TGFBI have been recognized to cause various types of CDs, including granular corneal dystrophies (GCDs), lattice CD type 1, Reis–Bucklers CD, and Thiel–Benke CD, as well as some other atypical CDs (Han et al., 2016). This evidence concerns the gene TGFBI and cerebral creatine deficiency syndrome.