To further investigate the role of Nrf2 in the control of HSV-2-induced type I IFN and HSV-2 replication, mRNA levels of Ifnβ1 were monitored by qPCR following virus infection in vitro (HSV-2, strain MS, titer 1 × 108 PFU/mL). The gene discussed is NFE2L2; the disease is viral infectious disease.