MASP-2, one of the serine proteases responsible for the activation of the lectin pathway, was recently implicated as an important mediator of ischemia/reperfusion injury in animal models and was shown to be significantly reduced in patients suffering from myocardial infarction, and anti-MASP-2 antibodies were shown to significantly reduce the risk of ischemic damage (26, 42). The gene discussed is MASP2; the disease is myocardial infarction.