In patients with SLE, when MDM were differentiated with LMP-IC, IL-1β, IL-6, and TNF-α levels did not increase after additional IL-4 treatment (Figures 4A,B), suggesting that these cells, but not MDM from HC and patients with RA, reversed the M1 profile induced by MP-IC (Supplementary Figure 5). The gene discussed is TNF; the disease is systemic lupus erythematosus.