CD8A and systemic lupus erythematosus: Interestingly, although CD8+ T cells from patients with SLE proliferated in response to MDM regardless of the presence of LMP and LPM-IC, an increased percentage of IFN-γ+ cells were observed in these lymphocytes when MDM were differentiated with LMP and LPM-IC compared with those differentiated without these vesicles (Figure 5).