The effect of MP and MP-IC in MDM, regarding changes in morphology (side and forward scatter), the expression of differentiation (HLA-DR, CD16, CD14, CCR2, and CD36) and activation (CD86, CD80, TLR-4, CD163, and CD209) markers and the expression of cytokine levels (IL-1β, IL-6, TNF-α, IL-10, IL-8, and IL12p70) were evaluated in mononuclear phagocytes obtained from HC and patients with RA and SLE, differentiated without (MDM-Unstimulated, -Unstim) or with extracellular vesicles (MP from SLE: MDM-LMP and MDM-LMP-IC; MP from RA: MDM-RMP and MDM-RMP-IC). The gene discussed is CD80; the disease is rheumatoid arthritis.