PTGER2 and neoplasm: In this context, we demonstrated that the coculture of PDAC Colo357 and other tumor cells such as breast cancer, MDA-MB-231, and cervical cancer HeLa cell lines with Vδ2 T cells increased the prostaglandin (PG) synthetase cyclooxygenase (COX)-2 expression in tumor cells and thereby the release of PGE2, which in turn significantly inhibited Vδ2 T cell-mediated cytotoxicity (48).