In lung adenocarcinoma murine models, immunogenic chemotherapy (oxaliplatin-cyclophosphamide) has been reported to up-regulate toll-like receptor 4 (TLR-4) on tumor-infiltrating Batf3-cDCs, which leads to the recruitment of CTLs and sensitization to iCPIs (164). Here, TLR4 is linked to lung adenocarcinoma.