Type 1 TAMs (M1) produce immune stimulatory cytokines, like IL-6, IL-12 and CXCL9, that promote recruitment of CTLs, while type 2 TAMs (M2) exhibit an immune suppressive signature and support tumor growth by release of angiogenic factors, like IL-10 and CCL22, matrix remodeling mediated by proteases, and by inhibition of CTL and DC activity (150–153). Here, IL10 is linked to neoplasm.